Für Sie gelesen: A 3-Year Open-Label, Flexible-Dosing Study of Milnacipran for the Treatment of Fibromyalgia Efficacy of Long-Term Milnacipran Treatment in Patients Meeting Different Thresholds of Clinically Relevant Pain Relief: Subgroup
نویسنده
چکیده
Einleitung Fibromyalgie (FM) ist eine komplexe Schmerzerkrankung mit einer Prävalenz von rund 2–4 %. Neben der Schmerz-symptomatik leiden die Patienten häufig unter Symptomen wie Fatigue, Steifigkeit, Schlafstörung, depressive Verstim-mung oder kognitive Beeinträchtigung. Aufgrund der Chroni-zität der FM und der sich daraus ergebenden Notwendigkeit einer langfristigen Therapie sind die Dauerhaftigkeit der Wir-kung sowie die Sicherheit der Behandlung von größtem Inter-esse.
منابع مشابه
Efficacy of long-term milnacipran treatment in patients meeting different thresholds of clinically relevant pain relief: subgroup analysis of a randomized, double-blind, placebo-controlled withdrawal study
BACKGROUND Fibromyalgia patients from a long-term, open-label study of milnacipran (50-200 mg/day) were eligible to participate in a 12-week, randomized, placebo-controlled withdrawal study. The withdrawal study evaluated loss of therapeutic response in patients who achieved ≥50% pain improvements after receiving up to 3.25 years of milnacipran. This post-hoc analysis investigated whether patie...
متن کاملA 3-year, open-label, flexible-dosing study of milnacipran for the treatment of fibromyalgia.
OBJECTIVES To evaluate the effects of long-term milnacipran treatment in fibromyalgia patients. METHODS Patients completing a previous milnacipran study were eligible to participate in this long-term (up to 3.25 y), open-label study. After washout, dose escalation, and 8 weeks of stable-dose treatment (100 mg/d), patients received flexible doses of milnacipran (50 to 200 mg/d) for the remaind...
متن کاملContinuing efficacy of milnacipran following long-term treatment in fibromyalgia: a randomized trial
INTRODUCTION Previous studies of long-term treatment response in fibromyalgia and other chronic pain states have generally been limited to approximately one year, leaving questions about the longer-term durability of response. The purpose of this study was to demonstrate continuing efficacy of milnacipran by characterizing changes in pain and other fibromyalgia symptoms after discontinuing long...
متن کاملDurability of therapeutic response to milnacipran treatment for fibromyalgia. Results of a randomized, double-blind, monotherapy 6-month extension study.
OBJECTIVE To evaluate the durability of improvement and long-term efficacy of milnacipran treatment in fibromyalgia, to assess efficacy in patients re-randomized from placebo to milnacipran, and to collect additional information on the tolerability and efficacy of long-term treatment with milnacipran. DESIGN A total of 449 patients who successfully completed a 6-month lead-in study enrolled i...
متن کاملMilnacipran combined with pregabalin in fibromyalgia: a randomized, open-label study evaluating the safety and efficacy of adding milnacipran in patients with incomplete response to pregabalin.
OBJECTIVE To evaluate the safety, tolerability, and efficacy of adding milnacipran to pregabalin in patients with fibromyalgia who have experienced an incomplete response to pregabalin. METHODS In this randomized, multicenter, open-label study, patients received pregabalin 300 or 450 mg/day during a 4- to 12-week run-in period. Patients with weekly recall visual analog scale (VAS) pain score ...
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